TRR 295

Retuning dynamic motor network disorders using neuromodulation

Collaborative Research Centre TRR 295 ReTune

GENERAL INFORMATION

Our TRR 295 seeks to improve the understanding of the various symptoms of human movement disorders by elucidating symptom-specific neural activity and developing specific treatment strategies for network modulation in common and clinically-relevant neurological diseases. We hypothesize that neuromodulation is a promising tool that can modify network activity and restore motor function by eliminating pathological network activity, augmenting normal interareal communication, or activating compensatory circuits.

We strongly believe that only a unifying, comprehensive, and multidisciplinary effort that brings together experts from neurobiology, neurophysiology, computational modeling and neuroimaging, mathematics, engineering, psychology, neurology, and neurosurgery has the potential to realize this vision within the coming decade. A structured program to train a new generation of neuroscientists with broad scientific and methodological expertise will strengthen our research efforts. We will simultaneously study experimental interventions in well-described model systems and analyze the mechanisms of established neuromodulation therapies based on quantifiable motor outcomes in patients, for rapid translation from bench to bedside and vice versa.

Project Groups

Area A

CELL TO CELL INTERACTIONS IN MOTOR DISEASE NETWORK

TRR 295 ReTune Area A
This research area will focus on the microcircuitry of motor disease networks and the bidirectional interplay between dysfunction at the global network and cellular levels. We will build upon the general hypothesis that structural and functional changes within brain networks intersect at the cellular level.

Area B

CIRCUIT MODELING AND IMAGING OF MOTOR DISEASE NETWORKS

TRR 295 ReTune Area B
This research area will focus on characterizing information processing within the cortico-basal ganglia-cerebellar motor network, considering both local neuronal dynamics and distributed large-scale interactions in the motor networks in health and disease, using multimodal imaging and computational approaches.

Area C

RETUNING MOTOR DISEASE NETWORKS

TRR 295 ReTune Area C
This research area aims to optimize neuromodulation therapy by exploring novel spatiotemporal stimulation algorithms and adaptive neurostimulation, and the potential for disease-modifying actions by invasive and non-invasive stimulation techniques.

Area Z

CORE PROJECTS

TRR 295 ReTune Area Z
Core projects will provide quality assurance and data management services, as well as cutting-edge, open-source software solutions for the co-registration of electrode locations and neurostimulation fields, next to the central administrative project.

Project Leaders

TRR 295 ReTune Spokesperson

Prof.
Andrea Kühn

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TRR 295 ReTune Project Leader

Prof.
Jens Volkmann

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TRR 295 ReTune Project Leader

Prof.
Alfons Schnitzler

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TRR 295 ReTune Project Leader

Prof.
Andreas Buck

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TRR 295 ReTune Project Leader

Prof.
Chi Wang Ip

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TRR 295 ReTune Project Leader

Prof.
Christoph Harms

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TRR 295 ReTune Project Leader

Prof.
Cordula Matthies

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TRR 295 ReTune Project Leader

Prof.
Esther Florin

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TRR 295 ReTune Project Leader

Prof.
Gabriel Curio

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TRR 295 ReTune Project Leader

Dr.
Gerd-Helge Schneider

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TRR 295 ReTune Project Leader

Prof.
Hagai Bergman

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TRR 295 ReTune Project Leader

Prof.
Ioannis Isaias

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TRR 295 ReTune Project Leader

Prof.
John-Dylan Haynes

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TRR 295 ReTune Project Leader

Prof.
Jörg Geiger

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TRR 295 ReTune Project Leader

Prof.
Julian Neumann

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TRR 295 ReTune Project Leader

Prof.
Matthias Endres

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TRR 295 ReTune Project Leader

Prof.
Michael Rosenblum

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TRR 295 ReTune Project Leader

Dr.
Michael Schuhmann

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TRR 295 ReTune Project Leader

Prof.
Michael Sendtner

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TRR 295 ReTune Project Leader

Dr.
Nikolaus Wenger

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TRR 295 ReTune Project Leader

Prof.
Peter Heuschmann

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TRR 295 ReTune Project Leader

Prof.
Petra Ritter

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TRR 295 ReTune Project Leader

Prof.
Philip Tovote

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TRR 295 ReTune Project Leader

PD Dr.
Robert Blum

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TRR 295 ReTune Project Leader

PD Dr.
Robert Preissner

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TRR 295 ReTune Project Leader

Dr.
Stefan Haufe

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TRR 295 ReTune Project Leader

Prof.
Ursula van Rienen

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TRR 295 ReTune Project Leader

Dr.
Vadim Nikulin

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