Collaborative Research Centre TRR 295 ReTune
Our TRR 295 seeks to improve the understanding of the various symptoms of human movement disorders by elucidating symptom-specific neural activity and developing specific treatment strategies for network modulation in common and clinically-relevant neurological diseases. We hypothesize that neuromodulation is a promising tool that can modify network activity and restore motor function by eliminating pathological network activity, augmenting normal interareal communication, or activating compensatory circuits.
We strongly believe that only a unifying, comprehensive, and multidisciplinary effort that brings together experts from neurobiology, neurophysiology, computational modeling and neuroimaging, mathematics, engineering, psychology, neurology, and neurosurgery has the potential to realize this vision within the coming decade. A structured program to train a new generation of neuroscientists with broad scientific and methodological expertise will strengthen our research efforts. We will simultaneously study experimental interventions in well-described model systems and analyze the mechanisms of established neuromodulation therapies based on quantifiable motor outcomes in patients, for rapid translation from bench to bedside and vice versa.